Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion

It is established that hematopoietic stem cells (HSC) in the hypoxic bone marrow have adapted their metabolism to oxygen-limiting conditions. This adaptation includes suppression of mitochondrial activity, induction of anerobic glycolysis, and activation of hypoxia-inducible transcription factor 1α...

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Détails bibliographiques
Publié dans:Cell Death Dis
Auteurs principaux: Bejarano-García, José Antonio, Millán-Uclés, África, Rosado, Iván V, Sánchez-Abarca, Luís Ignacio, Caballero-Velázquez, Teresa, Durán-Galván, María José, Pérez-Simón, José Antonio, Piruat, José I
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5261010/
https://ncbi.nlm.nih.gov/pubmed/27929539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.411
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