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Genotoxicity of tetrahydrofolic acid to hematopoietic stem and progenitor cells
Metabolically reactive formaldehyde is a genotoxin and a carcinogen. Mice lacking the main formaldehyde-detoxifying gene Adh5 combined with the loss of the Fanconi anemia (FA) DNA repair pathway rapidly succumbed to bone marrow failure (BMF) primarily due to the extensive ablation of the hematopoiet...
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| Gepubliceerd in: | Cell Death Differ |
|---|---|
| Hoofdauteurs: | , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Publishing Group UK
2018
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6219486/ https://ncbi.nlm.nih.gov/pubmed/29511342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0089-4 |
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