Genotoxicity of tetrahydrofolic acid to hematopoietic stem and progenitor cells

Metabolically reactive formaldehyde is a genotoxin and a carcinogen. Mice lacking the main formaldehyde-detoxifying gene Adh5 combined with the loss of the Fanconi anemia (FA) DNA repair pathway rapidly succumbed to bone marrow failure (BMF) primarily due to the extensive ablation of the hematopoiet...

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Udgivet i:Cell Death Differ
Main Authors: García-Calderón, Clara B., Bejarano-García, José Antonio, Tinoco-Gago, Isabel, Castro, María José, Moreno-Gordillo, Paula, Piruat, José I., Caballero-Velázquez, Teresa, Pérez-Simón, José A., Rosado, Iván V.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219486/
https://ncbi.nlm.nih.gov/pubmed/29511342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0089-4
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