Genotoxicity of tetrahydrofolic acid to hematopoietic stem and progenitor cells

Metabolically reactive formaldehyde is a genotoxin and a carcinogen. Mice lacking the main formaldehyde-detoxifying gene Adh5 combined with the loss of the Fanconi anemia (FA) DNA repair pathway rapidly succumbed to bone marrow failure (BMF) primarily due to the extensive ablation of the hematopoiet...

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Détails bibliographiques
Publié dans:Cell Death Differ
Auteurs principaux: García-Calderón, Clara B., Bejarano-García, José Antonio, Tinoco-Gago, Isabel, Castro, María José, Moreno-Gordillo, Paula, Piruat, José I., Caballero-Velázquez, Teresa, Pérez-Simón, José A., Rosado, Iván V.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6219486/
https://ncbi.nlm.nih.gov/pubmed/29511342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0089-4
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