A Conditional Mouse Mutant in the Tumor Suppressor SdhD Gene Unveils a Link between p21(WAF1/Cip1) Induction and Mitochondrial Dysfunction

Mutations in mitochondrial complex II (MCII; succinate dehydrogenase, Sdh) genes cause familiar pheochromocytoma/paraganglioma tumors. Several mechanisms have been proposed to account for Sdh-mutation-induced tumorigenesis, the most accepted of which is based on the constitutive expression of the hy...

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Autori principali: Millán-Uclés, África, Díaz-Castro, Blanca, García-Flores, Paula, Báez, Alicia, Pérez-Simón, José Antonio, López-Barneo, José, Piruat, José I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896393/
https://ncbi.nlm.nih.gov/pubmed/24465590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0085528
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