RDNA-05. SYNTHETIC SENSITIZATION OF MGMT-DEFICIENT TUMOR CELLS TO TEMOZOLOMIDE USING ATR INHIBITORS

BACKGROUND: Glioblastoma (GBM) is the most common primary brain tumor in adults. The current standard of care consists of surgery followed by temozolomide (TMZ) and radiation therapy (RT). TMZ is an alkylating agent that methylates guanine bases at the O(6) position (O(6)meG). O(6)-meG-methyltransfe...

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Bibliografski detalji
Izdano u:Neuro Oncol
Glavni autori: Jackson, Christopher, Noorbakhsh, Seth, Sundaram, Ranjini, Kalathil, Aravind, Bindra, Ranjit
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
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Abstracts
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217510/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.921
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