RDNA-05. SYNTHETIC SENSITIZATION OF MGMT-DEFICIENT TUMOR CELLS TO TEMOZOLOMIDE USING ATR INHIBITORS

BACKGROUND: Glioblastoma (GBM) is the most common primary brain tumor in adults. The current standard of care consists of surgery followed by temozolomide (TMZ) and radiation therapy (RT). TMZ is an alkylating agent that methylates guanine bases at the O(6) position (O(6)meG). O(6)-meG-methyltransfe...

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Publicado no:Neuro Oncol
Main Authors: Jackson, Christopher, Noorbakhsh, Seth, Sundaram, Ranjini, Kalathil, Aravind, Bindra, Ranjit
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217510/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.921
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