RDNA-05. SYNTHETIC SENSITIZATION OF MGMT-DEFICIENT TUMOR CELLS TO TEMOZOLOMIDE USING ATR INHIBITORS

BACKGROUND: Glioblastoma (GBM) is the most common primary brain tumor in adults. The current standard of care consists of surgery followed by temozolomide (TMZ) and radiation therapy (RT). TMZ is an alkylating agent that methylates guanine bases at the O(6) position (O(6)meG). O(6)-meG-methyltransfe...

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發表在:Neuro Oncol
Main Authors: Jackson, Christopher, Noorbakhsh, Seth, Sundaram, Ranjini, Kalathil, Aravind, Bindra, Ranjit
格式: Artigo
語言:Inglês
出版: Oxford University Press 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217510/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.921
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