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EXTH-55. TEMOZOLOMIDE-RESISTANT GLIOMA CELLS ARE SENSITIVE TO CHLOROETHYLATING NITROSOUREA COMPOUNDS IN COMBINATION WITH ATR INHIBITORS
BACKGROUND: Despite decades of research, nearly all patients with glioblastoma (GBM) face recurrent disease. Temozolomide (TMZ), the drug of choice for GBM, methylates guanine bases at the O(6) position (O(6)meG). These lesions are normally repaired by O(6)meG-methyltransferase (MGMT). When MGMT is...
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| Publicado en: | Neuro Oncol |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6847612/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.386 |
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