Temozolomide sensitizes MGMT-deficient tumor cells to ATR inhibitors

O(6)-methylguanine-DNA methyltransferase (MGMT) is an enzyme that removes alkyl groups at the O(6)-position of guanine in DNA. MGMT expression is reduced or absent in many tumor types derived from a diverse range of tissues, most notably in glioma. Low MGMT expression confers significant sensitivity...

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Publicado en:Cancer Res
Autores principales: Jackson, Christopher B., Noorbakhsh, Seth I., Sundaram, Ranjini K., Kalathil, Aravind N., Ganesa, Sachita, Jia, Lanqi, Breslin, Hank, Burgenske, Danielle M., Gilad, Oren, Sarkaria, Jann N., Bindra, Ranjit S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6810597/
https://ncbi.nlm.nih.gov/pubmed/31273061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-3394
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