Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide

BACKGROUND: The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) can cause resistance to the alkylating drug temozolomide (TMZ). The purpose of this study was to determine the relationship between the MGMT status, determined by means of several techniques and methods, and the cytot...

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Hlavní autoři: van Nifterik, K A, van den Berg, J, van der Meide, W F, Ameziane, N, Wedekind, L E, Steenbergen, R D M, Leenstra, S, Lafleur, M V M, Slotman, B J, Stalpers, L J A, Sminia, P
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2010
Témata:
Translational Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905289/
https://ncbi.nlm.nih.gov/pubmed/20517307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605712
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