Absence of the MGMT protein as well as methylation of the MGMT promoter predict the sensitivity for temozolomide

BACKGROUND: The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) can cause resistance to the alkylating drug temozolomide (TMZ). The purpose of this study was to determine the relationship between the MGMT status, determined by means of several techniques and methods, and the cytot...

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Библиографические подробности
Главные авторы: van Nifterik, K A, van den Berg, J, van der Meide, W F, Ameziane, N, Wedekind, L E, Steenbergen, R D M, Leenstra, S, Lafleur, M V M, Slotman, B J, Stalpers, L J A, Sminia, P
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2010
Предметы:
Translational Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2905289/
https://ncbi.nlm.nih.gov/pubmed/20517307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605712
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