Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53

Malignant melanomas are highly resistant to chemotherapy. First-line chemotherapeutics used in melanoma therapy are the methylating agents dacarbazine (DTIC) and temozolomide (TMZ) and the chloroethylating agents BCNU and fotemustine. Here, we determined the mode of cell death in 11 melanoma cell li...

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Bibliografiske detaljer
Main Authors: Naumann, S C, Roos, W P, Jöst, E, Belohlavek, C, Lennerz, V, Schmidt, C W, Christmann, M, Kaina, B
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2009
Fag:
Translational Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634706/
https://ncbi.nlm.nih.gov/pubmed/19127257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604856
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