Temozolomide- and fotemustine-induced apoptosis in human malignant melanoma cells: response related to MGMT, MMR, DSBs, and p53

Malignant melanomas are highly resistant to chemotherapy. First-line chemotherapeutics used in melanoma therapy are the methylating agents dacarbazine (DTIC) and temozolomide (TMZ) and the chloroethylating agents BCNU and fotemustine. Here, we determined the mode of cell death in 11 melanoma cell li...

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Detalhes bibliográficos
Main Authors: Naumann, S C, Roos, W P, Jöst, E, Belohlavek, C, Lennerz, V, Schmidt, C W, Christmann, M, Kaina, B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634706/
https://ncbi.nlm.nih.gov/pubmed/19127257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604856
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