Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression

BACKGROUND: The use of temozolomide (TMZ) has improved the prognosis for glioblastoma multiforme patients. However, TMZ resistance may be one of the main reasons why treatment fails. Although this resistance has frequently been linked to the expression of O6-methylguanine-DNA methyltransferase (MGMT...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Perazzoli, Gloria, Prados, Jose, Ortiz, Raul, Caba, Octavio, Cabeza, Laura, Berdasco, Maria, Gónzalez, Beatriz, Melguizo, Consolación
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598115/
https://ncbi.nlm.nih.gov/pubmed/26447477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140131
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