Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression

BACKGROUND: The use of temozolomide (TMZ) has improved the prognosis for glioblastoma multiforme patients. However, TMZ resistance may be one of the main reasons why treatment fails. Although this resistance has frequently been linked to the expression of O6-methylguanine-DNA methyltransferase (MGMT...

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Udgivet i:PLoS One
Main Authors: Perazzoli, Gloria, Prados, Jose, Ortiz, Raul, Caba, Octavio, Cabeza, Laura, Berdasco, Maria, Gónzalez, Beatriz, Melguizo, Consolación
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598115/
https://ncbi.nlm.nih.gov/pubmed/26447477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140131
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