Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression

BACKGROUND: The use of temozolomide (TMZ) has improved the prognosis for glioblastoma multiforme patients. However, TMZ resistance may be one of the main reasons why treatment fails. Although this resistance has frequently been linked to the expression of O6-methylguanine-DNA methyltransferase (MGMT...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Perazzoli, Gloria, Prados, Jose, Ortiz, Raul, Caba, Octavio, Cabeza, Laura, Berdasco, Maria, Gónzalez, Beatriz, Melguizo, Consolación
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4598115/
https://ncbi.nlm.nih.gov/pubmed/26447477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0140131
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