The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide

BACKGROUND: Promoter methylation of O(6)-methylguanine-DNA methyltransferase (MGMT) is an important predictive biomarker in glioblastoma. The T variant of the MGMT promoter-enhancer single nucleotide polymorphism (SNP; rs16906252) has been associated with the presence of MGMT promoter methylation in...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Rapkins, Robert W., Wang, Fan, Nguyen, HuyTram N., Cloughesy, Timothy F., Lai, Albert, Ha, Wendy, Nowak, Anna K., Hitchins, Megan P., McDonald, Kerrie L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2015
Konular:
Basic and Translational Investigations
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633927/
https://ncbi.nlm.nih.gov/pubmed/25910840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nov064
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