EG-11 DYSREGULATION OF MGMT IN GLIOBLASTOMA: FRIEND OR FOE?

Por Rapkins, Robert W., Hitchins, Megan P., McDonald, Kerrie L.
Publicado em 2014

Identification of constitutional MLH1 epimutations and promoter variants in colorectal cancer patients from the Colon Cancer Family Registry

Por Ward, Robyn L., Dobbins, Timothy, Lindor, Noralane M., Rapkins, Robert W., Hitchins, Megan P.
Publicado em 2013

Expression of GBGT1 is epigenetically regulated by DNA methylation in ovarian cancer cells

Por Jacob, Francis, Hitchins, Megan P, Fedier, André, Brennan, Kevin, Nixdorf, Sheri, Hacker, Neville F, Ward, Robyn, Heinzelmann-Schwarz, Viola A
Publicado em 2014

The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide

Por Rapkins, Robert W., Wang, Fan, Nguyen, HuyTram N., Cloughesy, Timothy F., Lai, Albert, Ha, Wendy, Nowak, Anna K., Hitchins, Megan P., McDonald, Kerrie L.
Publicado no Neuro Oncol (2015)

Conflicting Reports of Imprinting Status of Human GRB10 in Developing Brain: How Reliable Are Somatic Cell Hybrids for Predicting Allelic Origin of Expression?

Por Mergenthaler, Susanne, Hitchins, Megan P., Blagitko-Dorfs, Nadya, Monk, David, Wollmann, Hartmut A., Ranke, Michael B., Ropers, Hans-Hilger, Apostolidou, Sophia, Stanier, Philip, Preece, Michael A., Eggermann, Thomas, Kalscheuer, Vera M., Moore, Gudrun E.
Publicado em 2001

De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in...

Por Goel, Ajay, Nguyen, Thuy-Phuong, Leung, Hon-Chiu E., Nagasaka, Takeshi, Rhees, Jennifer, Hotchkiss, Erin, Arnold, Mildred, Banerji, Pia, Koi, Minoru, Kwok, Chau-To, Packham, Deborah, Lipton, Lara, Boland, C. Richard, Ward, Robyn L., Hitchins, Megan P.
Publicado em 2011

The MLH1 c.-27C>A and c.85G>T variants are linked to dominantly inherited MLH1 epimutation and are borne on a European ancestral haplotype

Por Kwok, Chau-To, Vogelaar, Ingrid P, van Zelst-Stams, Wendy A, Mensenkamp, Arjen R, Ligtenberg, Marjolijn J, Rapkins, Robert W, Ward, Robyn L, Chun, Nicolette, Ford, James M, Ladabaum, Uri, McKinnon, Wendy C, Greenblatt, Marc S, Hitchins, Megan P
Publicado em 2014

SNP rs16906252C>T is an expression and methylation quantitative trait locus associated with an increased risk of developing MGMT-methylated colorectal cancer

Por Kuroiwa-Trzmielina, Joice, Wang, Fan, Rapkins, Robert W., Ward, Robyn L., Buchanan, Daniel D., Win, Aung Ko, Clendenning, Mark, Rosty, Christophe, Southey, Melissa C., Winship, Ingrid M., Hopper, John L., Jenkins, Mark A., Olivier, Jake, Hawkins, Nicholas J., Hitchins, Megan P.
Publicado no Clin Cancer Res (2016)