De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one

Lynch syndrome is an autosomal dominant cancer predisposition syndrome classically caused by germline mutations of the mismatch repair genes, MLH1, MSH2, MSH6 and PMS2. Constitutional epimutations of the MLH1 gene, characterized by soma-wide methylation of a single allele of the promoter and allelic...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Goel, Ajay, Nguyen, Thuy-Phuong, Leung, Hon-Chiu E., Nagasaka, Takeshi, Rhees, Jennifer, Hotchkiss, Erin, Arnold, Mildred, Banerji, Pia, Koi, Minoru, Kwok, Chau-To, Packham, Deborah, Lipton, Lara, Boland, C. Richard, Ward, Robyn L., Hitchins, Megan P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794437/
https://ncbi.nlm.nih.gov/pubmed/20473912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25422
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados