De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one

Lynch syndrome is an autosomal dominant cancer predisposition syndrome classically caused by germline mutations of the mismatch repair genes, MLH1, MSH2, MSH6 and PMS2. Constitutional epimutations of the MLH1 gene, characterized by soma-wide methylation of a single allele of the promoter and allelic...

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Bibliografiske detaljer
Main Authors:	Goel, Ajay, Nguyen, Thuy-Phuong, Leung, Hon-Chiu E., Nagasaka, Takeshi, Rhees, Jennifer, Hotchkiss, Erin, Arnold, Mildred, Banerji, Pia, Koi, Minoru, Kwok, Chau-To, Packham, Deborah, Lipton, Lara, Boland, C. Richard, Ward, Robyn L., Hitchins, Megan P.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2011
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3794437/ https://ncbi.nlm.nih.gov/pubmed/20473912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25422
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De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one

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