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EG-11 DYSREGULATION OF MGMT IN GLIOBLASTOMA: FRIEND OR FOE?

Glioblastoma (GBM) is the most common and lethal form of brain cancer (median survival <15 months). The DNA alkylating agent, temozolomide, is used as the standard chemotherapeutic agent, resulting in mispairing of guanine with thymidine that leads to cellular arrest. However, in GBM patients the...

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Autors principals: Rapkins, Robert W., Hitchins, Megan P., McDonald, Kerrie L.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218089/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou254.11
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