Second signals rescue B cells from activation-induced mitochondrial dysfunction and death

B cells are activated by two temporally distinct signals, the first provided by antigen binding to the B cell antigen receptor (BCR) and the second by T helper cells. Here we show that B cells responded to antigen by rapidly increasing metabolic activity including both oxidative phosphorylation and...

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Detaylı Bibliyografya
Yayımlandı:Nat Immunol
Asıl Yazarlar: Akkaya, Munir, Traba, Javier, Roesler, Alexander S., Miozzo, Pietro, Akkaya, Billur, Theall, Brandon P., Sohn, Haewon, Pena, Mirna, Smelkinson, Margery, Kabat, Juraj, Dahlstrom, Eric, Dorward, David W., Skinner, Jeff, Sack, Michael N., Pierce, Susan K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202187/
https://ncbi.nlm.nih.gov/pubmed/29988090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0156-5
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