Second signals rescue B cells from activation-induced mitochondrial dysfunction and death

B cells are activated by two temporally distinct signals, the first provided by antigen binding to the B cell antigen receptor (BCR) and the second by T helper cells. Here we show that B cells responded to antigen by rapidly increasing metabolic activity including both oxidative phosphorylation and...

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Библиографические подробности
Опубликовано в: :Nat Immunol
Главные авторы: Akkaya, Munir, Traba, Javier, Roesler, Alexander S., Miozzo, Pietro, Akkaya, Billur, Theall, Brandon P., Sohn, Haewon, Pena, Mirna, Smelkinson, Margery, Kabat, Juraj, Dahlstrom, Eric, Dorward, David W., Skinner, Jeff, Sack, Michael N., Pierce, Susan K.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202187/
https://ncbi.nlm.nih.gov/pubmed/29988090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0156-5
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