Second signals rescue B cells from activation-induced mitochondrial dysfunction and death

B cells are activated by two temporally distinct signals, the first provided by antigen binding to the B cell antigen receptor (BCR) and the second by T helper cells. Here we show that B cells responded to antigen by rapidly increasing metabolic activity including both oxidative phosphorylation and...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nat Immunol
Autori principali: Akkaya, Munir, Traba, Javier, Roesler, Alexander S., Miozzo, Pietro, Akkaya, Billur, Theall, Brandon P., Sohn, Haewon, Pena, Mirna, Smelkinson, Margery, Kabat, Juraj, Dahlstrom, Eric, Dorward, David W., Skinner, Jeff, Sack, Michael N., Pierce, Susan K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202187/
https://ncbi.nlm.nih.gov/pubmed/29988090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0156-5
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi