Second signals rescue B cells from activation-induced mitochondrial dysfunction and death

B cells are activated by two temporally distinct signals, the first provided by antigen binding to the B cell antigen receptor (BCR) and the second by T helper cells. Here we show that B cells responded to antigen by rapidly increasing metabolic activity including both oxidative phosphorylation and...

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Publicat a:Nat Immunol
Autors principals: Akkaya, Munir, Traba, Javier, Roesler, Alexander S., Miozzo, Pietro, Akkaya, Billur, Theall, Brandon P., Sohn, Haewon, Pena, Mirna, Smelkinson, Margery, Kabat, Juraj, Dahlstrom, Eric, Dorward, David W., Skinner, Jeff, Sack, Michael N., Pierce, Susan K.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202187/
https://ncbi.nlm.nih.gov/pubmed/29988090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0156-5
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