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Toll-like receptor 9 antagonizes antibody affinity maturation

Key events in T cell-dependent antibody responses, including affinity maturation, are dependent on the B cell’s presentation of antigen to helper T cells at critical check points in germinal center formation in secondary lymphoid organs. Here we show that Toll-like receptor 9 (TLR9) signaling blocke...

詳細記述

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書誌詳細
出版年:Nat Immunol
主要な著者: Akkaya, Munir, Akkaya, Billur, Kim, Ann S., Miozzo, Pietro, Sohn, Haewon, Pena, Mirna, Roesler, Alexander S., Theall, Brandon P., Henke, Travis, Kabat, Juraj, Lu, Jinghua, Dorward, David W., Dahlstrom, Eric, Skinner, Jeff, Miller, Louis H., Pierce, Susan K.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5839995/
https://ncbi.nlm.nih.gov/pubmed/29476183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0052-z
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