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Fragment-Based Discovery of 8-Hydroxyquinoline Inhibitors of the HIV-1 Integrase-LEDGF/p75 Interaction
On the basis of an initial molecular modeling study suggesting the favorable binding of the “privileged” fragment 8-hydroxyquinoline with IN at the IN-LEDGF/p75 interface, we developed a set of modified 8-hydroxyquinoline fragments demonstrating micromolar IC(50) values for inhibition of the IN-LEDG...
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| Udgivet i: | J Med Chem |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6188675/ https://ncbi.nlm.nih.gov/pubmed/23445471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301632e |
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