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Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions

Human lens epithelium-derived growth factor (LEDGF)/p75 plays an important role in the HIV life cycle by stimulating integrase (IN)-led viral DNA integration into cellular chromosomes. Mechanistic studies show the majority of IN inhibitors chelate magnesium ions in the catalytic active site, a regio...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Sanchez, Tino Wilson, Debnath, Bikash, Christ, Frauke, Otake, Hiroyuki, Debyser, Zeger, Neamati, Nouri
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6188659/
https://ncbi.nlm.nih.gov/pubmed/23306052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.12.012
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