Chargement en cours...
Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions
Human lens epithelium-derived growth factor (LEDGF)/p75 plays an important role in the HIV life cycle by stimulating integrase (IN)-led viral DNA integration into cellular chromosomes. Mechanistic studies show the majority of IN inhibitors chelate magnesium ions in the catalytic active site, a regio...
Enregistré dans:
| Publié dans: | Bioorg Med Chem |
|---|---|
| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2012
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6188659/ https://ncbi.nlm.nih.gov/pubmed/23306052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.12.012 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|