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Discovery of novel inhibitors of LEDGF/p75-IN protein-protein interactions
Human lens epithelium-derived growth factor (LEDGF)/p75 plays an important role in the HIV life cycle by stimulating integrase (IN)-led viral DNA integration into cellular chromosomes. Mechanistic studies show the majority of IN inhibitors chelate magnesium ions in the catalytic active site, a regio...
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| 發表在: | Bioorg Med Chem |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6188659/ https://ncbi.nlm.nih.gov/pubmed/23306052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.12.012 |
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