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A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication
HIV-1 integrase (IN) is an important target for contemporary antiretroviral drug design research. Historically, efforts at inactivating the enzyme have focused upon blocking its active site. However, it has become apparent that new classes of allosteric inhibitors will be necessary to advance the an...
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| Główni autorzy: | , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Public Library of Science
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3445459/ https://ncbi.nlm.nih.gov/pubmed/23028829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045177 |
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