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A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication
HIV-1 integrase (IN) is an important target for contemporary antiretroviral drug design research. Historically, efforts at inactivating the enzyme have focused upon blocking its active site. However, it has become apparent that new classes of allosteric inhibitors will be necessary to advance the an...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3445459/ https://ncbi.nlm.nih.gov/pubmed/23028829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045177 |
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