A Symmetric Region of the HIV-1 Integrase Dimerization Interface Is Essential for Viral Replication

HIV-1 integrase (IN) is an important target for contemporary antiretroviral drug design research. Historically, efforts at inactivating the enzyme have focused upon blocking its active site. However, it has become apparent that new classes of allosteric inhibitors will be necessary to advance the an...

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Main Authors: Serrao, Erik, Thys, Wannes, Demeulemeester, Jonas, Al-Mawsawi, Laith Q., Christ, Frauke, Debyser, Zeger, Neamati, Nouri
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445459/
https://ncbi.nlm.nih.gov/pubmed/23028829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045177
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