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Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization

Targeting the HIV integrase (HIV IN) is a clinically validated approach for designing novel anti-HIV therapies. We have previously described the discovery of a novel class of integration inhibitors, 2-(quinolin-3-yl)acetic acid derivatives, blocking HIV replication at a low micromolar concentration...

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主要な著者: Christ, Frauke, Shaw, Stephen, Demeulemeester, Jonas, Desimmie, Belete A., Marchand, Arnaud, Butler, Scott, Smets, Wim, Chaltin, Patrick, Westby, Mike, Debyser, Zeger, Pickford, Chris
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2012
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421592/
https://ncbi.nlm.nih.gov/pubmed/22664975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00717-12
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