Pharmacological characterization of levorphanol, a G-protein biased opioid analgesic

BACKGROUND: Levorphanol is a potent analgesic that has been used for decades. Most commonly used for acute and cancer pain, it also is effective against neuropathic pain. The recent appreciation of the importance of functional bias and the uncovering of multiple mu opioid receptor splice variants ma...

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Veröffentlicht in:Anesth Analg
Hauptverfasser: Le Rouzic, Valerie, Narayan, Ankita, Hunkle, Amanda, Marrone, Gina F., Lu, Zhigang, Majumdar, Susruta, Xu, Jin, Pan, Ying-Xian, Pasternak, Gavril W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6181797/
https://ncbi.nlm.nih.gov/pubmed/29649035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1213/ANE.0000000000003360
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