Different Response of Ptch Mutant and Ptch Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors

Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS frequently show Hedgehog (HH) pathway activity, which is predominantly seen in the embryonal subtype (ERMS). They also show activation of Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) signaling....

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Geyer, Natalie, Ridzewski, Rosalie, Bauer, Julia, Kuzyakova, Maria, Dittmann, Kai, Dullin, Christian, Rosenberger, Albert, Schildhaus, Hans-Ulrich, Uhmann, Anja, Fulda, Simone, Hahn, Heidi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168716/
https://ncbi.nlm.nih.gov/pubmed/30319965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00396
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