Different Response of Ptch Mutant and Ptch Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors

Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS frequently show Hedgehog (HH) pathway activity, which is predominantly seen in the embryonal subtype (ERMS). They also show activation of Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) signaling....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Oncol
Egile Nagusiak: Geyer, Natalie, Ridzewski, Rosalie, Bauer, Julia, Kuzyakova, Maria, Dittmann, Kai, Dullin, Christian, Rosenberger, Albert, Schildhaus, Hans-Ulrich, Uhmann, Anja, Fulda, Simone, Hahn, Heidi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2018
Gaiak:
Oncology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168716/
https://ncbi.nlm.nih.gov/pubmed/30319965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00396
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