Calcitriol Inhibits Hedgehog Signaling and Induces Vitamin D Receptor Signaling and Differentiation in the Patched Mouse Model of Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Aberrant Hedgehog (Hh) signaling is characteristic of the embryonal subtype (ERMS) and of fusion-negative alveolar RMS. In the mouse, ERMS-like tumors can be induced by mutations in the Hh receptor Patched1 (Ptch). As in huma...

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Detalhes bibliográficos
Main Authors: Uhmann, Anja, Niemann, Hannah, Lammering, Bérénice, Henkel, Cornelia, Heß, Ina, Rosenberger, Albert, Dullin, Christian, Schraepler, Anke, Schulz-Schaeffer, Walter, Hahn, Heidi
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329653/
https://ncbi.nlm.nih.gov/pubmed/22550417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/357040
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