Calcitriol Inhibits Hedgehog Signaling and Induces Vitamin D Receptor Signaling and Differentiation in the Patched Mouse Model of Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Aberrant Hedgehog (Hh) signaling is characteristic of the embryonal subtype (ERMS) and of fusion-negative alveolar RMS. In the mouse, ERMS-like tumors can be induced by mutations in the Hh receptor Patched1 (Ptch). As in huma...

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Библиографические подробности
Главные авторы: Uhmann, Anja, Niemann, Hannah, Lammering, Bérénice, Henkel, Cornelia, Heß, Ina, Rosenberger, Albert, Dullin, Christian, Schraepler, Anke, Schulz-Schaeffer, Walter, Hahn, Heidi
Формат: Artigo
Язык:Inglês
Опубликовано: Hindawi Publishing Corporation 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3329653/
https://ncbi.nlm.nih.gov/pubmed/22550417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/357040
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