Different Response of Ptch Mutant and Ptch Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors

Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS frequently show Hedgehog (HH) pathway activity, which is predominantly seen in the embryonal subtype (ERMS). They also show activation of Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) signaling....

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Detalles Bibliográficos
Publicado en:Front Oncol
Autores principales: Geyer, Natalie, Ridzewski, Rosalie, Bauer, Julia, Kuzyakova, Maria, Dittmann, Kai, Dullin, Christian, Rosenberger, Albert, Schildhaus, Hans-Ulrich, Uhmann, Anja, Fulda, Simone, Hahn, Heidi
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2018
Materias:
Oncology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168716/
https://ncbi.nlm.nih.gov/pubmed/30319965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00396
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