PI3K Inhibition Enhances Doxorubicin-Induced Apoptosis in Sarcoma Cells

We searched for a drug capable of sensitization of sarcoma cells to doxorubicin (DOX). We report that the dual PI3K/mTOR inhibitor PI103 enhances the efficacy of DOX in several sarcoma cell lines and interacts with DOX in the induction of apoptosis. PI103 decreased the expression of MDR1 and MRP1, w...

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Detalhes bibliográficos
Main Authors: Marklein, Diana, Graab, Ulrike, Naumann, Ivonne, Yan, Tiandong, Ridzewski, Rosalie, Nitzki, Frauke, Rosenberger, Albert, Dittmann, Kai, Wienands, Jürgen, Wojnowski, Leszek, Fulda, Simone, Hahn, Heidi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534123/
https://ncbi.nlm.nih.gov/pubmed/23300809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052898
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