Dexrazoxane may prevent doxorubicin-induced DNA damage via depleting both Topoisomerase II isoforms

BACKGROUND: The bisdioxopiperazine dexrazoxane (DRZ) prevents anthracycline-induced heart failure, but its clinical use is limited by uncertain cardioprotective mechanism and by concerns of interference with cancer response to anthracyclines and of long-term safety. METHODS: We investigated the effe...

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Pubblicato in:BMC Cancer
Autori principali: Deng, Shiwei, Yan, Tiandong, Jendrny, Cathleen, Nemecek, Andrea, Vincetic, Mladen, Gödtel-Armbrust, Ute, Wojnowski, Leszek
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4242484/
https://ncbi.nlm.nih.gov/pubmed/25406834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-842
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