The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells

BACKGROUND AND PURPOSE: The catalytic topoisomerase II inhibitor dexrazoxane has been associated not only with improved cancer patient survival but also with secondary malignancies and reduced tumour response. EXPERIMENTAL APPROACH: We investigated the DNA damage response and the role of the activat...

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Publicat a:Br J Pharmacol
Autors principals: Deng, Shiwei, Yan, Tiandong, Nikolova, Teodora, Fuhrmann, Dominik, Nemecek, Andrea, Gödtel-Armbrust, Ute, Kaina, Bernd, Wojnowski, Leszek
Format: Artigo
Idioma:Inglês
Publicat: BlackWell Publishing Ltd 2015
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4403091/
https://ncbi.nlm.nih.gov/pubmed/25521189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13046
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