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DNA breaks and chromosomal aberrations arise when replication meets base excision repair

Exposures that methylate DNA potently induce DNA double-strand breaks (DSBs) and chromosomal aberrations, which are thought to arise when damaged bases block DNA replication. Here, we demonstrate that DNA methylation damage causes DSB formation when replication interferes with base excision repair (...

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Detalhes bibliográficos
Main Authors: Ensminger, Michael, Iloff, Lucie, Ebel, Christian, Nikolova, Teodora, Kaina, Bernd, Lӧbrich, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085701/
https://ncbi.nlm.nih.gov/pubmed/24982429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201312078
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