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DNA breaks and chromosomal aberrations arise when replication meets base excision repair
Exposures that methylate DNA potently induce DNA double-strand breaks (DSBs) and chromosomal aberrations, which are thought to arise when damaged bases block DNA replication. Here, we demonstrate that DNA methylation damage causes DSB formation when replication interferes with base excision repair (...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4085701/ https://ncbi.nlm.nih.gov/pubmed/24982429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201312078 |
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