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Hedgehog Inhibitors in Rhabdomyosarcoma: A Comparison of Four Compounds and Responsiveness of Four Cell Lines

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and is divided into two major histological subgroups, i.e., embryonal (ERMS) and alveolar RMS (ARMS). RMS can show HEDGEHOG/SMOOTHENED (HH/SMO) signaling activity and several clinical trials using HH inhibitors for therapy of...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Ridzewski, Rosalie, Rettberg, Diana, Dittmann, Kai, Cuvelier, Nicole, Fulda, Simone, Hahn, Heidi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4459089/
https://ncbi.nlm.nih.gov/pubmed/26106586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2015.00130
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