Different Response of Ptch Mutant and Ptch Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors

Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS frequently show Hedgehog (HH) pathway activity, which is predominantly seen in the embryonal subtype (ERMS). They also show activation of Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) signaling....

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Bibliographische Detailangaben
Veröffentlicht in:Front Oncol
Hauptverfasser: Geyer, Natalie, Ridzewski, Rosalie, Bauer, Julia, Kuzyakova, Maria, Dittmann, Kai, Dullin, Christian, Rosenberger, Albert, Schildhaus, Hans-Ulrich, Uhmann, Anja, Fulda, Simone, Hahn, Heidi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168716/
https://ncbi.nlm.nih.gov/pubmed/30319965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00396
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