Different Response of Ptch Mutant and Ptch Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors

Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS frequently show Hedgehog (HH) pathway activity, which is predominantly seen in the embryonal subtype (ERMS). They also show activation of Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) signaling....

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Front Oncol
Päätekijät: Geyer, Natalie, Ridzewski, Rosalie, Bauer, Julia, Kuzyakova, Maria, Dittmann, Kai, Dullin, Christian, Rosenberger, Albert, Schildhaus, Hans-Ulrich, Uhmann, Anja, Fulda, Simone, Hahn, Heidi
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Frontiers Media S.A. 2018
Aiheet:
Oncology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6168716/
https://ncbi.nlm.nih.gov/pubmed/30319965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2018.00396
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