Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers

The HIV-1-envelope glycoprotein (Env) is the main target of antigen design for antibody-based prophylactic vaccines. The generation of broadly neutralizing antibodies (bNAb) likely requires the appropriate presentation of stabilized trimers preventing exposure of non-neutralizing antibody (nNAb) epi...

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Publicado en:Cell Rep
Main Authors: Aldon, Yoann, McKay, Paul F., Allen, Joel, Ozorowski, Gabriel, Felfödiné Lévai, Réka, Tolazzi, Monica, Rogers, Paul, He, Linling, de Val, Natalia, Fábián, Katalin, Scarlatti, Gabriella, Zhu, Jiang, Ward, Andrew B., Crispin, Max, Shattock, Robin J.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6167709/
https://ncbi.nlm.nih.gov/pubmed/30232012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.08.051
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