Persistent immunogenicity of integrase defective lentiviral vectors delivering membrane-tethered native-like HIV-1 envelope trimers

Abstract Integrase Defective Lentiviral Vectors (IDLVs) represent an attractive vaccine platform for delivering HIV-1 antigens, given their ability to induce specific and persistent immune responses in both mice and non-human primates (NHPs). Recent advances in HIV-1 immunogen design demonstrated th...

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Main Authors: Alessandra Gallinaro, Maria Franca Pirillo, Yoann Aldon, Serena Cecchetti, Zuleika Michelini, Antonella Tinari, Martina Borghi, Andrea Canitano, Paul F. McKay, Roberta Bona, Maria Fenicia Vescio, Felicia Grasso, Maria Blasi, Silvia Baroncelli, Gabriella Scarlatti, Celia LaBranche, David Montefiori, Mary E. Klotman, Rogier W. Sanders, Robin J. Shattock, Donatella Negri, Andrea Cara
Format: Artigo
Jezik:Inglês
Izdano: Nature Portfolio 2022-04-01
Serija:npj Vaccines
Online dostop:https://doi.org/10.1038/s41541-022-00465-1
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