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Cytotoxic and mutagenic properties of O(6)-alkyl-2′-deoxyguanosine lesions in Escherichia coli cells

Environmental exposure and cellular metabolism can give rise to DNA alkylation, which can occur on the nitrogen and oxygen atoms of nucleobases, as well as on the phosphate backbone. Although O(6)-alkyl-2′-deoxyguanosine (O(6)-alkyl-dG) lesions are known to be associated with cancer, not much is kno...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Wang, Pengcheng, Wang, Yinsheng
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166734/
https://ncbi.nlm.nih.gov/pubmed/30068548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004676
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