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Cytotoxic and mutagenic properties of O(6)-alkyl-2′-deoxyguanosine lesions in Escherichia coli cells
Environmental exposure and cellular metabolism can give rise to DNA alkylation, which can occur on the nitrogen and oxygen atoms of nucleobases, as well as on the phosphate backbone. Although O(6)-alkyl-2′-deoxyguanosine (O(6)-alkyl-dG) lesions are known to be associated with cancer, not much is kno...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6166734/ https://ncbi.nlm.nih.gov/pubmed/30068548 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004676 |
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