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Cytotoxic and mutagenic properties of O(4)-alkylthymidine lesions in Escherichia coli cells

Due to the abundant presence of alkylating agents in living cells and the environment, DNA alkylation is generally unavoidable. Among the alkylated DNA lesions, O(4)-alkylthymidine (O(4)-alkyldT) are known to be highly mutagenic and persistent in mammalian tissues. Not much is known about how the st...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Wang, Pengcheng, Amato, Nicholas J., Zhai, Qianqian, Wang, Yinsheng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678858/
https://ncbi.nlm.nih.gov/pubmed/26400162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv941
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