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Cytotoxic and mutagenic properties of O(4)-alkylthymidine lesions in Escherichia coli cells

Due to the abundant presence of alkylating agents in living cells and the environment, DNA alkylation is generally unavoidable. Among the alkylated DNA lesions, O(4)-alkylthymidine (O(4)-alkyldT) are known to be highly mutagenic and persistent in mammalian tissues. Not much is known about how the st...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Wang, Pengcheng, Amato, Nicholas J., Zhai, Qianqian, Wang, Yinsheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4678858/
https://ncbi.nlm.nih.gov/pubmed/26400162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv941
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