Protein Targeting Chimeric Molecules Specific for Bromodomain and Extra-terminal Motif Family Proteins are Active Against Pre-Clinical Models of Multiple Myeloma

Bromodomain and extraterminal (BET) domain containing protein (BRD)-4 modulates the expression of oncogenes such as c-myc, and is a promising therapeutic target in diverse cancer types. We performed pre-clinical studies in myeloma models with bi-functional protein-targeting chimeric molecules (PROTA...

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Библиографические подробности
Опубликовано в: :Leukemia
Главные авторы: Zhang, Xiaohui, Lee, Hans C., Shirazi, Fazal, Baladandayuthapani, Veerabhadran, Lin, Heather, Kuiatse, Isere, Wang, Hua, Jones, Richard J., Berkova, Zuzana, Singh, Ram Kumar, Lu, Jing, Qian, Yimin, Raina, Kanak, Coleman, Kevin G., Crews, Craig M., Li, Bingzong, Wang, Huihan, Hailemichael, Yared, Thomas, Sheeba K., Wang, Zhiqiang, Davis, R. Eric, Orlowski, Robert Z.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160356/
https://ncbi.nlm.nih.gov/pubmed/29581547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0044-x
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