Targeting Myddosome Signaling in Waldenström’s Macroglobulinemia with the Interleukin-1 Receptor-associated Kinase 1/4 Inhibitor R191

PURPOSE: Waldenström’s macroglobulinemia is an incurable lymphoproliferative disorder driven by an L265P mutation in the Myeloid differentiation primary response gene 88 (MYD88), which activates downstream Nuclear factor kappa-B (NF-κB) signaling through the Myddosome. As this pathway depends in par...

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Publicado no:Clin Cancer Res
Main Authors: Haiwen, Ni, Shirazi, Fazal, Baladandayuthapani, Veerabhadran, Lin, Heather, Kuiatse, Isere, Wang, Hua, Jones, Richard J., Berkova, Zuzana, Hitoshi, Yasumichi, Ansell, Stephen M., Treon, Steven P., Thomas, Sheeba K., Lee, Hans C., Wang, Zhiqiang, Davis, R. Eric, Orlowski, Robert Z.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295253/
https://ncbi.nlm.nih.gov/pubmed/30126942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-3265
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