REVERBa couples the circadian clock to hepatic glucocorticoid action

The glucocorticoid receptor (GR) is a major drug target in inflammatory disease. However, chronic glucocorticoid (GC) treatment leads to disordered energy metabolism, including increased weight gain, adiposity, and hepatosteatosis — all programs modulated by the circadian clock. We demonstrated that...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Caratti, Giorgio, Iqbal, Mudassar, Hunter, Louise, Kim, Donghwan, Wang, Ping, Vonslow, Ryan M., Begley, Nicola, Tetley, Abigail J., Woodburn, Joanna L., Pariollaud, Marie, Maidstone, Robert, Donaldson, Ian J., Zhang, Zhenguang, Ince, Louise M., Kitchen, Gareth, Baxter, Matthew, Poolman, Toryn M., Daniels, Dion A., Stirling, David R., Brocker, Chad, Gonzalez, Frank, Loudon, Andrew S.I., Bechtold, David A., Rattray, Magnus, Matthews, Laura C., Ray, David W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160001/
https://ncbi.nlm.nih.gov/pubmed/30179226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI96138
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