The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia

The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core clock protein BMAL1 in macrophages confers protection against pneumococcal pneumonia. Infected mice show both red...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kitchen, Gareth B., Cunningham, Peter S., Poolman, Toryn M., Iqbal, Mudassar, Maidstone, Robert, Baxter, Matthew, Bagnall, James, Begley, Nicola, Saer, Ben, Hussell, Tracy, Matthews, Laura C., Dockrell, David H., Durrington, Hannah J., Gibbs, Julie E., Blaikley, John F., Loudon, Andrew S., Ray, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983378/
https://ncbi.nlm.nih.gov/pubmed/31900362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915932117
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