The circadian regulator BMAL1 programmes responses to parasitic worm infection via a dendritic cell clock

Resistance to the intestinal parasitic helminth Trichuris muris requires T-helper 2 (T(H)2) cellular and associated IgG1 responses, with expulsion typically taking up to 4 weeks in mice. Here, we show that the time-of-day of the initial infection affects efficiency of worm expulsion, with strong T(H...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Hopwood, Thomas W., Hall, Sarah, Begley, Nicola, Forman, Ruth, Brown, Sheila, Vonslow, Ryan, Saer, Ben, Little, Matthew C., Murphy, Emma A., Hurst, Rebecca J., Ray, David W., MacDonald, Andrew S., Brass, Andy, Bechtold, David A., Gibbs, Julie E., Loudon, Andrew S., Else, Kathryn J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5830501/
https://ncbi.nlm.nih.gov/pubmed/29491349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22021-5
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