The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia

The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core clock protein BMAL1 in macrophages confers protection against pneumococcal pneumonia. Infected mice show both red...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Kitchen, Gareth B., Cunningham, Peter S., Poolman, Toryn M., Iqbal, Mudassar, Maidstone, Robert, Baxter, Matthew, Bagnall, James, Begley, Nicola, Saer, Ben, Hussell, Tracy, Matthews, Laura C., Dockrell, David H., Durrington, Hannah J., Gibbs, Julie E., Blaikley, John F., Loudon, Andrew S., Ray, David W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6983378/
https://ncbi.nlm.nih.gov/pubmed/31900362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915932117
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