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The circadian clock protein REVERBα inhibits pulmonary fibrosis development

Pulmonary inflammatory responses lie under circadian control; however, the importance of circadian mechanisms in the underlying fibrotic phenotype is not understood. Here, we identify a striking change to these mechanisms resulting in a gain of amplitude and lack of synchrony within pulmonary fibrot...

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מידע ביבליוגרפי
הוצא לאור ב:Proc Natl Acad Sci U S A
Main Authors: Cunningham, Peter S., Meijer, Peter, Nazgiewicz, Alicja, Anderson, Simon G., Borthwick, Lee A., Bagnall, James, Kitchen, Gareth B., Lodyga, Monika, Begley, Nicola, Venkateswaran, Rajamiyer V., Shah, Rajesh, Mercer, Paul F., Durrington, Hannah J., Henderson, Neil C., Piper-Hanley, Karen, Fisher, Andrew J., Chambers, Rachel C., Bechtold, David A., Gibbs, Julie E., Loudon, Andrew S., Rutter, Martin K., Hinz, Boris, Ray, David W., Blaikley, John F.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969503/
https://ncbi.nlm.nih.gov/pubmed/31879343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912109117
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