The circadian clock protein REVERBα inhibits pulmonary fibrosis development

Pulmonary inflammatory responses lie under circadian control; however, the importance of circadian mechanisms in the underlying fibrotic phenotype is not understood. Here, we identify a striking change to these mechanisms resulting in a gain of amplitude and lack of synchrony within pulmonary fibrot...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Cunningham, Peter S., Meijer, Peter, Nazgiewicz, Alicja, Anderson, Simon G., Borthwick, Lee A., Bagnall, James, Kitchen, Gareth B., Lodyga, Monika, Begley, Nicola, Venkateswaran, Rajamiyer V., Shah, Rajesh, Mercer, Paul F., Durrington, Hannah J., Henderson, Neil C., Piper-Hanley, Karen, Fisher, Andrew J., Chambers, Rachel C., Bechtold, David A., Gibbs, Julie E., Loudon, Andrew S., Rutter, Martin K., Hinz, Boris, Ray, David W., Blaikley, John F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969503/
https://ncbi.nlm.nih.gov/pubmed/31879343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912109117
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